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Marc Aucoin
Assistant Professor
Office: E6 4012
Phone: 519-888-4567 ext. 36084
Email: maucoin@uwaterloo.ca
Degrees: BASc, MASc, University of Waterloo; PhD,
Ecole Polytechnique de Montréal
Personal Homepage |
Research Interests
Process dynamics of virus-based systems for the production of complex biologics such as viral vectors and vaccines, and the development of strategies using multiple viruses to obtain recombinant products in cell culture.
Selected References
- Transfiguracion, J., Mena, J.A., Aucoin, M.G., Kamen, A.A. Quantification and Validation of Baculovirus Particles using HPLC, Journal of Chromatography B, DOI:10.1016/j.jchromb.2010.11.011.
- Sokolenko, S., Cheng, Y.-L., Aucoin, M.G. Getting more from cell size distributions: establishing more accurate biovolumes by estimating viable cell populations, Biotechnology Progress, DOI: 10.1002/btpr.486.
- Aucoin, M.G., Mena, J.A., Kamen, A.A. (2010). Bioprocessing of baculovirus vectors: A review, Current Gene Therapy, 10(3), 2010, 174-186.
- Mena, J.A., Aucoin, M.G., Montes, J., Chahal, P.S., Kamen A.A. (2010). Improving Adeno-Associated Vector Yield In High Density Insect Cell Cultures, Journal of Gene Medicine, 12 (2), 157-167.
- Aucoin, M.G., Jolicoeur, M. (2009). Is there room in the graduate curriculum to learn how to be a graduate student? An approach using a graduate-level biochemical engineering course, Chemical Engineering Education, 43 (4), 2009, 306-312.
- Aucoin, M.G., Perrier, M., Kamen A.A. (2008). Critical assessment of current adeno-associated viral vector production and quantification methods, Biotechnology Advances, 26 (1), 73 – 88.
- Aucoin, M.G., Perrier, M., Kamen, A.A. (2007). Improving AAV vector yield in insect cells by modulating the temperature after infection, Biotechnology and Bioengineering, 97 (6), 1501-1509.
- Aucoin, M.G., Jacob, D., Chahal, P.S., Meghrous, J., Bernier, A., Kamen, A.A. (2007). Virus-like Particle and Viral Vector Production Using the BEV/insect Cell System: Adeno-associated Virus Based Products, Methods in Molecular Biology, vol. 338: Baculovirus and Insect Cell Expression Protocols, 2nd Edition, Totowa, New Jersey, Humana Press Inc., 281-296.
- Aucoin, M.G., Perrier, M., Kamen, A.A. (2006). Production of adeno-associated viral vectors in insect cells using triple infection: optimization of baculovirus concentration ratios, Biotechnology and Bioengineering, 95 (6), 1081-1092.
- Aucoin, M.G., McMurray-Beaulieu, V., Poulin, F., Boivin, E.B., Chen, J., Ardelean, F.M., Cloutier, M., Choi, Y.J., Miguez, C.B., Jolicoeur, M. (2006). Identifying conditions for inducible protein production in E. coli: combining a fed-batch and multiple induction approach, Microbial Cell Factories, 5 (27).
- Chahal, P.S., Aucoin, M.G., Kamen, A.A. (2007). Primary recovery and chromatographic purification of Adeno-Associated virus type 2 produced by Baculovirus/insect cell system, Journal of Virological Methods, 139 (1), 61-70.
- Meghrous, J., Aucoin, M.G., Jacob, D., Chahal, P.S., Arcand, N., Kamen, A.A., Production of recombinant adeno-associated viral vectors using a
baculovirus/insect cell suspension culture system: from shake flasks to a 20-L
bioreactor, Biotechnology Progress, 21(1), 154-60, Jan-Feb 2005.
- Aucoin, M.G., Erhardt, F.A., Legge, R.L., Hyperactivation of Rhizomucor miehei lipase by hydrophobic xerogels, Biotechnology and Bioengineering, 85(6), 647-55, Mar 2004.
- Aucoin, M.G., Legge, R.L. (2001). Effect of Supercritical CO2 Exposure on Immobilized Lipase Activity, Biotechnology Letters, 23(22), 1863-1870.
